Possible protective effects of gallic acid against hepatic ischemia-reperfusion injury in rats Sıçanlarda karaciğer iskemi-reperfüzyon hasarına karşı gallik asitin olası koruyucu etkisi

AIM: The protective effect of gallic acid (3,4,5trihydroxybenzoic acid), which is a phenolic substance with well-known antioxidant characteristics, against liver ischemia reperfusion damage was investigated in this study. METHODS: Female Spraque-dawley rats were divided into four groups. Group I was set as control group and 60 minutes of reperfusion after 45 minutes of ischemia was applied to the other three groups. Gallic acid was administered through gavage method to each of the animals in Group III and Group IV for seven days prior to Ischemia/Reperfusion. Blood samples for biochemical examinations and liver tissue samples for histologic examinations were collected. RESULT: When Group II was compared with other groups in terms of ALT and AST serum values, a significant increase was observed in Group II serum amount. ALT levels of Group III (50 mg/kg gallic acid) and Group IV (100 mg/kg gallic acid) among treatment groups were found lower compared to Group II (I/R group) (p<0.05). When AST serum values were considered, the serum amount pertaining to group III was found to be significantly lower when compared with other groups (p<0.05). Histological findings are in line with these results. CONCLUSION: In accordance with the obtained results, we may state that gallic acid protects against liver ischemia reperfusion damage.